Research Interests
Raluca Borlan is a postdoctoral researcher and a member of the Nanobiophotonics and Laser Microspectroscopy Centre (NLMC, nanobiophotonics.ro) of the Interdisciplinary Research Institute in Bio-Nano-Sciences, Babe?-Bolyai University (BBU), Cluj-Napoca, Romania.
She has an ongoing research interest focused on two complementary topics: the development and characterization of nanoparticles as multimodal therapeutic and contrast agents, and the investigation of their multimodal effects and therapeutic potential in solution, in vitro, and in vivo, including their use in sensing applications. She has gained genuine expertise in the design and implementation of nano-sized carriers as sensors, photothermal, and contrast agents.
Expertise
• Design and development of magnetic and organic nanoparticles for biomedical applications
• Synthesis, functionalization, and physicochemical characterization of nanomaterials (UV-Vis, fluorescence, DLS, zeta potential)
• Nanoparticles biofunctionalization for targeted delivery, therapy, selective biosensing and fluorescence-guided imaging
• Preparation and analysis of agarose-based and biological phantoms for theranostic studies
• Evaluation of nanoparticle biocompatibility and cellular uptake (in vitro and ex vivo)
• Phototherapy techniques (PDT and PTT) using laser or LED irradiation — applied in solution, in vitro, and in vivo experiments
• Optical microscopy (confocal microscopy, fluorescence microscopy)
International visibility
ORCID iD: 0000-0003-3581-3020 - orcid.org
BrainMap ID: U-1900-061V-8864 - brainmap.ro
Google Scholar: scholar.google.com
Email: raluca.borlan@ubbcluj.ro
Phone: +40 264 454554/ int 117
Most Relevant Publications
Antioxidant Activity Evaluation and Assessment of the Binding Affinity to HSA of a New Catechol Hydrazinyl-Thiazole Derivative, M Mic, A Pîrnău, C G Floare, R Borlan, M Focsan, O Oniga, M Bogdan, L Vlase, I Oniga, G Marc, Antioxidants 11 (7), 1245 (2022)
Antibody Functionalized Theranostic Protein Nanoparticles for Synergistic Deep Red Fluorescence Imaging and Multimodal Therapy of Ovarian Cancer, R Borlan, M Focsan, M Perde-Schrepler, O Soritau, A Campu, L Gaina, E Pall, B Pop, O Baldasici, C Gherman, D Stoia, D Maniu and S Astilean, Biomaterials Science (2021)
Fluorescent phthalocyanine-encapsulated bovine serum albumin nanoparticles: their deployment as therapeutic agents in the NIR region, R Borlan, D Stoia, L Gaina, A Campu, G Marc, M Perde-Schrepler, M Silion, D Maniu, M Focsan and S Astilean; Molecules, 26(15): 4697 (2021)
Interventional NIR Fluorescence Imaging of Cancer: Review on Next Generation of Dye Loaded Protein-Based Nanoparticles for Real-Time Feedback During Cancer Surgery, R Borlan, M Focsan, D Maniu, and S Astilean, International Journal of Nanomedicine, 16: 2147–71 (2021)
Design of Fluorophore Loaded Human Serum Albumin Nanoparticles for Specific Targeting of NIH:OVCAR3 Ovarian Cancer Cells, R. Borlan, A-S. Tatar, O. Sorita, D. Maniu, G. Marc, A. Florea, M. Focsan, S. Astilean, Nanotechnology, 31(31): 315102 (2020).